SCHEMBL18544403

SCHEMBL18544403

COc1ccc(O)c(Cl)c1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.42
HIF1A Q16665 1/20 0.41
EPAS1 Q99814 1/20 0.41
TUBB1 Q9H4B7 1/20 0.41
CYP3A4 P08684 3/20 0.40
TP53 P04637 2/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
TSHR P16473 1/20 0.40
CYP17A1 P05093 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
RET P07949 1/20 0.39
KIF5B P33176 1/20 0.39
KDR P35968 1/20 0.39
MAPK1 P28482 3/20 0.39
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPT P10636 2/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23537773 0.83 MAOB (0.42) MAOBHIF1AEPAS1TUBB1CYP3A4
SCHEMBL19756651 0.82 MAPT (0.41) TUBB1CYP3A4CA1CA2CYP17A1
SCHEMBL714254 0.80 MAOB (0.46) MAOBHIF1AEPAS1TUBB1CYP3A4
SCHEMBL11151784 0.80 MAPK1 (0.48) MAOBHIF1AEPAS1CYP3A4TP53
SCHEMBL19756643 0.78 HTR2A (0.46) TUBB1CYP3A4CA1CA2CYP17A1
SCHEMBL5469559 0.78 MAPK1 (0.52) MAOBHIF1AEPAS1TUBB1CYP3A4
SCHEMBL19756656 0.78 HTR2A (0.46) TUBB1CYP3A4TSHRCYP17A1CYP11B1
SCHEMBL9035273 0.77 MAPT (0.44) MAOBHIF1AEPAS1TUBB1CYP3A4
SCHEMBL18494758 0.77 TUBB1 (0.41) TUBB1CYP3A4CA1CA2CYP17A1
SCHEMBL22207921 0.76 EPHX2 (0.37) CYP3A4TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865475-A1 PROCESS FOR PREPARING PYRIDONE AMIDES WHICH ARE MODULATORS OF SODIUM CHANNELS AND INTERMEDIATE COMPOUNDS USED THEREIN Vertex Pharmaceuticals Incorporated (US) 2021-08-18 EP disclosed
EP-3239134-B1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMA (US) 2020-12-23 EP disclosed
EP-3239134-A1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS Vertex Pharmaceuticals Incorporated (US) 2017-11-01 EP disclosed
EP-2953931-B1 PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMA (US) 2017-03-01 EP disclosed