Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.48 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854517 | 0.85 | SPHK2 (0.43) | ACHEBCHESPHK2SPHK1ALDH1A1 | |
| SCHEMBL1853006 | 0.83 | ALDH1A1 (0.46) | SPHK2SPHK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1851801 | 0.83 | SPHK1 (0.41) | ACHEBCHESPHK2SPHK1ALDH1A1 | |
| SCHEMBL5044858 | 0.77 | ALDH1A1 (0.40) | SPHK2SPHK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1851803 | 0.75 | CHRM2 (0.40) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL6022341 | 0.75 | ALDH1A1 (0.46) | SPHK2SPHK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7064619 | 0.75 | ALDH1A1 (0.46) | SPHK1ALDH1A1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL5044699 | 0.75 | ALDH1A1 (0.46) | SPHK2SPHK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1853076 | 0.74 | SPHK1 (0.47) | ACHEBCHESPHK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1853005 | 0.74 | SPHK1 (0.47) | ACHEBCHESPHK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |