Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047684 | 0.90 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL5044867 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL5039878 | 0.81 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL6802901 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL5044424 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL1853006 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL1851803 | 0.78 | CHRM2 (0.40) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL1854447 | 0.77 | ACHE (0.48) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL5039990 | 0.76 | SPHK1 (0.41) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD | |
| SCHEMBL7064619 | 0.76 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |