Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359640 | 0.89 | KDM4E (0.50) | ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL20352233 | 0.80 | KDM4E (0.43) | ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL8580833 | 0.79 | MAPT (0.54) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL24359638 | 0.78 | MAPT (0.43) | ALDH1A1KDM4EPOLBMAPTCYP1A2 | |
| SCHEMBL18538905 | 0.75 | KDM4E (0.48) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL14444588 | 0.75 | PAOX (0.46) | ALDH1A1KDM4EPOLBPAOXTSHR | |
| SCHEMBL14190592 | 0.73 | POLB (0.38) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL2701173 | 0.73 | POLB (0.38) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL11453595 | 0.73 | KDM4E (0.38) | ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL14444593 | 0.73 | ALDH1A1 (0.38) | ALDH1A1KDM4EPOLBPAOXMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3337483-B1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2019-10-09 | — | — | EP | disclosed |
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050952-A1 | NOVEL ANNELATED BENZAMIDES | HDAC10, HDAC11, H1-0 | ALDH1A1 168/4885KDM4E 862/4885POLB 3848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.