Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.30 |
| ▸ | AOC1 | P19801 | 9/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 9/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002207 | 0.97 | AOC1 (0.43) | AOC1AOC3LOXL2CYP2E1CYP2C8 | |
| SCHEMBL8011489 | 0.84 | AOC1 (0.38) | AOC1AOC3LOXL2CYP2E1CYP2C8 | |
| SCHEMBL844771 | 0.84 | CYP2E1 (0.43) | AOC1AOC3LOXL2CYP2E1CYP2C8 | |
| SCHEMBL21352027 | 0.84 | AOC1 (0.38) | AOC1AOC3LOXL2CYP2A6GAA | |
| SCHEMBL8013767 | 0.84 | AOC1 (0.38) | AOC1AOC3LOXL2CYP2E1CYP2C8 | |
| Bromide SCHEMBL23161956 | 0.79 | LOXL2 (0.61) | AOC1AOC3LOXL2 | |
| Bromide SCHEMBL29433932 | 0.79 | AOC1 (0.38) | AOC1AOC3LOXL2CYP2E1CYP2C8 | |
| Bromide SCHEMBL5042605 | 0.79 | AOC1 (0.38) | AOC1AOC3LOXL2 | |
| Bromide SCHEMBL844992 | 0.79 | GAA (0.45) | AOC1AOC3LOXL2SLC6A2SLC6A4 | |
| SCHEMBL2593605 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136326-B2 | Pyrrolopyrimidine derivatives as TAM inhibitors | INCYTE CORPORATION (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200181151-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | INCYTE CORPORATION | 2020-06-11 | — | — | US | disclosed |
| US-20190031663-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | INCYTE CORPORATION | 2019-01-31 | — | — | US | disclosed |
| US-10053465-B2 | Pyrrolopyrimidine derivatives as TAM inhibitors | INCYTE CORPORATION (US) | 2018-08-21 | — | — | US | disclosed |
| WO-2017035366-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-03-02 | — | — | WO | disclosed |
| US-20170057965-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | INCYTE CORPORATION | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136326-B2 | Pyrrolopyrimidine derivatives as TAM inhibitors | FLT3, MERTK, MIF | SLC6A2 4229/4885SLC6A4 4121/4885SIGMAR1 3403/4885 |
| US-20190031663-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | FLT3, MERTK, MIF | SLC6A2 4229/4885SLC6A4 4121/4885SIGMAR1 3403/4885 |
| US-10053465-B2 | Pyrrolopyrimidine derivatives as TAM inhibitors | FLT3, MERTK, MIF | SLC6A2 4229/4885SLC6A4 4121/4885SIGMAR1 3403/4885 |
| US-20200181151-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | FLT3, MERTK, MIF | SLC6A2 4229/4885SLC6A4 4121/4885SIGMAR1 3403/4885 |
| US-20170057965-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS TAM INHIBITORS | FLT3, MERTK, MIF | SLC6A2 4229/4885SLC6A4 4121/4885SIGMAR1 3403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.