Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.72 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.70 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.70 |
| ▸ | TUBB | P07437 | 1/20 | 0.70 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.70 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.70 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.70 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.70 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.70 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.70 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.70 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.70 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.70 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.70 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.70 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.70 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18550680 | 0.90 | OPRM1 (0.78) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL18550702 | 0.88 | OPRM1 (0.81) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL6114308 | 0.86 | MEN1 (0.78) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL18550688 | 0.85 | MEN1 (0.67) | OPRM1TRPV4MEN1KMT2ANPC1 | |
| SCHEMBL18550669 | 0.85 | MEN1 (0.70) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL18550666 | 0.84 | OPRM1 (1.00) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL18550636 | 0.83 | OPRM1 (0.83) | OPRM1TRPV4MEN1KMT2ANPC1 | |
| SCHEMBL18550672 | 0.83 | OPRM1 (1.00) | OPRM1TRPV4TUBB4ATUBBTUBA3C | |
| SCHEMBL8737943 | 0.81 | OPRM1 (0.60) | OPRM1TRPV4MEN1KMT2ANPC1 | |
| SCHEMBL18550682 | 0.80 | OPRM1 (1.00) | OPRM1TRPV4TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3344997-B1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | UNIV MINNESOTA (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3344997-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | Regents of the University of Minnesota (US) | 2018-07-11 | — | — | EP | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| US-9827228-B2 | Opioid receptor modulators and use thereof | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-11-28 | — | — | US | disclosed |
| WO-2017039778-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2017039778-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-02 | — | — | US | disclosed |
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-02 | — | — | US | disclosed |
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170056377-A1 | OPIOID RECEPTOR MODULATORS AND USE THEREOF | OPRM1, OPRK1, OPRL1 | OPRM1 1/4885TRPV4 202/4885TUBB4A 3138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.