Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19136021 | 0.90 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL15281425 | 0.90 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL23728786 | 0.90 | ALDH1A1 (0.55) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL18591884 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL25514096 | 0.84 | ALDH1A1 (0.54) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL22193215 | 0.80 | CYP1A2 (0.43) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL17165584 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL31498681 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL17165585 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPTHPGDLMNAPLA2G1B | |
| SCHEMBL872773 | 0.75 | BRD4 (0.49) | ALDH1A1MAPTHPGDLMNAPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017030814-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2017-02-23 | — | — | WO | disclosed |