Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 4/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213041 | 0.90 | ALDH1A1 (0.34) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL17213154 | 0.89 | GRK6 (0.39) | ALDH1A1TDP1GRK6TYMPLMNA | |
| SCHEMBL18552337 | 0.84 | CTSA (0.38) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL18540480 | 0.82 | MAPT (0.33) | ALDH1A1GRK6LMNASMN1; SMN2KMT2A | |
| SCHEMBL18552247 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL18552252 | 0.79 | GRK6 (0.37) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL17213070 | 0.79 | GRK6 (0.52) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL18552348 | 0.78 | MEN1 (0.39) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL18552365 | 0.78 | DHODH (0.40) | ALDH1A1TDP1GRK6TYMPKDM4E | |
| SCHEMBL18552307 | 0.78 | KDM4E (0.38) | ALDH1A1TDP1GRK6TYMPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050939-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | GRK6, GRK2, GRK3 | ALDH1A1 4745/4885TDP1 3509/4885GRK6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.