Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554287 | 1.00 | NAAA (0.57) | NAAANPC1TDP1ALDH1A1LMNA | |
| SCHEMBL18554201 | 0.82 | FFAR1 (0.53) | LMNA | |
| SCHEMBL18554199 | 0.82 | FFAR1 (0.53) | LMNA | |
| Hydrochloric Acid SCHEMBL18554214 | 0.81 | FFAR1 (0.51) | ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL18554213 | 0.81 | FFAR1 (0.51) | ALDH1A1MAPT | |
| SCHEMBL18554136 | 0.81 | HRH3 (0.46) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL18554135 | 0.81 | HRH3 (0.46) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL18576667 | 0.81 | HRH3 (0.46) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL18576607 | 0.81 | HRH3 (0.46) | NPC1RAB9AMEN1KMT2AHRH3 | |
| SCHEMBL18554139 | 0.81 | HRH3 (0.46) | NPC1RAB9AMEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |