Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | MME | P08473 | 6/20 | 0.52 |
| ▸ | CPA3 | P15088 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.46 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554199 | 1.00 | FFAR1 (0.53) | FFAR1MMECPA3NAALAD2MMEL1 | |
| Hydrochloric Acid SCHEMBL18554213 | 0.99 | FFAR1 (0.51) | FFAR1MMECPA3NAALAD2MMEL1 | |
| Hydrochloric Acid SCHEMBL18554214 | 0.99 | FFAR1 (0.51) | FFAR1MMECPA3NAALAD2MMEL1 | |
| SCHEMBL18554143 | 0.85 | MME (0.47) | MMEPPARGPPARA | |
| SCHEMBL18554144 | 0.85 | MME (0.47) | MMEPPARGPPARA | |
| SCHEMBL18554221 | 0.84 | PTGES (0.42) | FFAR1MMEPPARGPPARA | |
| SCHEMBL18554224 | 0.84 | PTGES (0.42) | FFAR1MMEPPARGPPARA | |
| SCHEMBL18554287 | 0.82 | NAAA (0.57) | LMNA | |
| SCHEMBL18554286 | 0.82 | NAAA (0.57) | LMNA | |
| SCHEMBL18554226 | 0.81 | ADRB1 (0.41) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |