Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950838 | 0.83 | PIM1 (0.40) | CDC7MAP2K1CLK4DYRK1BMAPK8 | |
| SCHEMBL3177261 | 0.83 | MAP4K4 (0.47) | NTRK1PIM1PARP1MKNK1MKNK2 | |
| SCHEMBL11906973 | 0.78 | IKBKB (0.40) | CDC7CLK4DYRK1BMAPK8PIM1 | |
| SCHEMBL4946402 | 0.76 | ERN1 (0.43) | HSD17B10MKNK1MKNK2IKBKB | |
| SCHEMBL4945696 | 0.73 | LIPG (0.42) | — | |
| SCHEMBL11907002 | 0.73 | MKNK1 (0.41) | CDC7POLBMKNK1MKNK2BTK | |
| SCHEMBL1551487 | 0.72 | MKNK1 (0.41) | CDC7PARP1TSHRL3MBTL1MKNK1 | |
| SCHEMBL2586506 | 0.71 | CDK8 (0.38) | CDC7MAP2K1DYRK1BMAPK8PIM1 | |
| SCHEMBL3232701 | 0.71 | SIRT3 (0.36) | NTRK1PIM1MAPTTSHRTDP1 | |
| SCHEMBL11907716 | 0.70 | MKNK1 (0.39) | CDC7ADORA2APOLBMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017034872-A1 | INDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | claimed |