Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 8/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950838 | 0.84 | PIM1 (0.40) | NTRK1PIM1ACVR1CASP1MKNK1 | |
| SCHEMBL18554602 | 0.83 | CDC7 (0.40) | NTRK1PIM1IKBKBMKNK1MKNK2 | |
| SCHEMBL4946402 | 0.77 | ERN1 (0.43) | KMOIKBKBMKNK1MKNK2 | |
| SCHEMBL2586506 | 0.75 | CDK8 (0.38) | MAP4K4PIM1ACVR1FYNMKNK1 | |
| SCHEMBL4945696 | 0.74 | LIPG (0.42) | — | |
| SCHEMBL11973162 | 0.73 | NOTUM (0.39) | MAP4K4KMORAB9A | |
| SCHEMBL14880353 | 0.72 | NOTUM (0.38) | MAP4K4KMORAB9A | |
| SCHEMBL11907002 | 0.71 | MKNK1 (0.41) | MKNK1MKNK2 | |
| SCHEMBL1551487 | 0.70 | MKNK1 (0.41) | IKBKBMKNK1MKNK2PARP1 | |
| SCHEMBL11906973 | 0.69 | IKBKB (0.40) | MAP4K4PIM1IKBKBMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252139-B1 | TRIFLUOROMETHYLPYRROLE CARBOXAMIDES AND TRIFLUOROMETHYLPYRROLETHIOAMIDES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-03-31 | — | — | EP | disclosed |
| US-7109150-B2 | Trifluoromethylpyrrolecarboxamides and trifluoromethylpyrrolethioamides as fungicides | SYNGENTA CROP PROTECTION, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040171490-A1 | Trifluoromethylpyrrolecarboxamides and Trifluoromethylpyrrolethioamides as fungicides | WALTER HARALD (CH) | 2004-09-02 | — | — | US | disclosed |
| US-6699818-B1 | CONTROLLING INFESTATION OF CULTIVATED PLANTS BY PHYTOPATHOGENIC MICROORGANISMS | SYNGENTA CROP PROTECTION, INC. | 2004-03-02 | — | — | US | disclosed |
| EP-1252139-A1 | TRIFLUOROMETHYLPYRROLE CARBOXAMIDES AND TRIFLUOROMETHYLPYRROLETHIOAMIDES AS FUNGICIDES | Syngenta Participations AG (CH) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001049664-A1 | TRIFLUOROMETHYLPYRROLE CARBOXAMIDES AND TRIFLUOROMETHYLPYRROLETHIOAMIDES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171490-A1 | Trifluoromethylpyrrolecarboxamides and Trifluoromethylpyrrolethioamides as fungicides | CBR3, CBR1, PYCR1 | MAP4K4 1466/4885NTRK1 4411/4885PIM1 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.