Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9660257 | 0.82 | DEGS1 (0.47) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL7995954 | 0.82 | TSHR (0.52) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL7995955 | 0.82 | TSHR (0.52) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL10830070 | 0.82 | TSHR (0.52) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL9450419 | 0.81 | DEGS1 (0.46) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL28390998 | 0.79 | DEGS1 (0.42) | DEGS1NR4A1NR4A2NR4A3CES2 | |
| SCHEMBL2205707 | 0.78 | MAPT (0.51) | DEGS1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2205704 | 0.78 | MAPT (0.51) | DEGS1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL5078615 | 0.78 | MAPT (0.51) | DEGS1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL28397010 | 0.78 | ELANE (0.49) | DEGS1SMN1; SMN2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340981-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035353-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |