Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555126 | 1.00 | SPHK1 (0.40) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL2038078 | 0.84 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL13555216 | 0.84 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL30639643 | 0.83 | LTA4H (0.41) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL14155228 | 0.80 | SCN3A (0.39) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL4491733 | 0.79 | SMN1; SMN2 (0.46) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL1031700 | 0.79 | SMN1; SMN2 (0.46) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL1530965 | 0.79 | SMN1; SMN2 (0.46) | SPHK1SCN3APOLBMAOAMAOB | |
| SCHEMBL6523272 | 0.78 | SMN1; SMN2 (0.40) | POLBLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3970845 | 0.78 | SMN1; SMN2 (0.44) | SPHK1SCN3APOLBMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340981-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | Achillion Pharmaceuticals, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035353-A1 | ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |