Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18555694 | 0.85 | PRMT5 (0.46) | PRMT5WDR77CCR2MEN1KMT2A | |
| SCHEMBL18555481 | 0.84 | FFAR1 (0.43) | PRMT5WDR77CCR2MEN1KMT2A | |
| SCHEMBL18555697 | 0.80 | PTGS2 (0.52) | CCR2MEN1KMT2APDE1B | |
| SCHEMBL11257792 | 0.79 | MEN1 (0.64) | MEN1KMT2AMAPTTBXA2RPTGDR2 | |
| SCHEMBL18180375 | 0.75 | APEX1 (0.57) | — | |
| SCHEMBL11262469 | 0.72 | TSHR (0.63) | KMT2AMAPTALDH1A1TSHR | |
| SCHEMBL10487857 | 0.70 | MAPT (0.64) | MEN1KMT2AMAPT | |
| SCHEMBL21382755 | 0.69 | PRMT5 (0.55) | PRMT5WDR77MEN1KMT2AMAPT | |
| SCHEMBL11481174 | 0.69 | APEX1 (0.60) | MEN1KMT2AMAPTPTGDR2ALDH1A1 | |
| SCHEMBL24093939 | 0.67 | MEN1 (0.44) | PRMT5WDR77CCR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017035415-A1 | ALKYNE COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |