Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 10/20 | 0.48 |
| ▸ | CCR6 | P51684 | 2/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14904750 | 0.80 | MMP2 (0.47) | CXCR2CXCR1CCR6CXCR3CCR4 | |
| SCHEMBL13970426 | 0.79 | CXCR2 (0.57) | CXCR2CXCR1CCR6 | |
| SCHEMBL14904751 | 0.78 | CXCR2 (0.55) | CXCR2CXCR1CCR6CXCR3CCR4 | |
| SCHEMBL14904749 | 0.76 | P2RX1 (0.50) | CXCR2CXCR1CCR6CXCR3CCR4 | |
| SCHEMBL14688342 | 0.73 | KMT2A (0.59) | — | |
| SCHEMBL8211190 | 0.70 | KDM4E (0.57) | CXCR2 | |
| SCHEMBL22090336 | 0.68 | NAPRT (0.49) | — | |
| SCHEMBL22108412 | 0.68 | TACR1 (0.34) | CXCR2CXCR1 | |
| SCHEMBL395688 | 0.67 | MLYCD (0.51) | — | |
| SCHEMBL8210808 | 0.67 | KDM4E (0.70) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580412-B2 | Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-02-28 | — | — | US | disclosed |