Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11075911 | 0.90 | CYP2C19 (0.54) | CYP2C19ACHEALOX5ALDH1A1LMNA | |
| SCHEMBL19407525 | 0.86 | CYP2C19 (0.48) | CYP2C19ACHEALOX5ALDH1A1LMNA | |
| SCHEMBL12883209 | 0.84 | GABBR2 (0.53) | CYP2C19ADRA2AADRA2BADRA2CLMNA | |
| SCHEMBL12836111 | 0.84 | GABBR2 (0.44) | ADRA2AADRA2BADRA2CHDAC8HDAC6 | |
| SCHEMBL22643582 | 0.84 | GABBR2 (0.44) | ADRA2AADRA2BADRA2CHDAC8HDAC6 | |
| SCHEMBL186231 | 0.83 | ALDH1A1 (0.56) | CYP2C19ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL186239 | 0.83 | ALDH1A1 (0.56) | CYP2C19ALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL29110964 | 0.83 | STAT3 (0.45) | CYP2C19ADRA2AADRA2BADRA2CHDAC8 | |
| SCHEMBL11322774 | 0.83 | FFAR1 (0.54) | CYP2C19HDAC8HDAC6ACHEALDH1A1 | |
| SCHEMBL27734567 | 0.83 | HTT (0.41) | CYP2C19ADRA2AADRA2BADRA2CHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401260-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097465-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-02 | — | — | WO | disclosed |