Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18558338 | 0.93 | GPR139 (0.38) | VNN1GPR139MAPK1MCHR1CDC7 | |
| SCHEMBL18558204 | 0.92 | VNN1 (0.40) | VNN1GPR139MCHR1CDC7DAPK3 | |
| SCHEMBL18558434 | 0.89 | HDAC3 (0.39) | GPR139HDAC2HDAC3HDAC4HDAC1 | |
| SCHEMBL18558028 | 0.89 | VNN1 (0.39) | VNN1GPR139MAPK1HDAC2PPARG | |
| SCHEMBL18558565 | 0.88 | VNN1 (0.39) | VNN1MAPK1MCHR1HDAC2HDAC3 | |
| SCHEMBL18558035 | 0.87 | MAPT (0.46) | VNN1 | |
| SCHEMBL18558579 | 0.86 | HDAC3 (0.44) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19362653 | 0.86 | VNN1 (0.38) | VNN1GPR139MAPK1HDAC2PPARG | |
| SCHEMBL9905160 | 0.85 | HDAC3 (0.36) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9905165 | 0.85 | HDAC3 (0.36) | HDAC2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932313-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-09-21 | — | — | US | disclosed |
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5F1D, ATP5ME | VNN1 2342/4885GPR139 4205/4885MAPK1 2483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.