Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22481395 | 0.80 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL22481391 | 0.77 | KCNJ1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3KCNJ1 | |
| SCHEMBL2737290 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL18558695 | 0.74 | APLNR (0.50) | KCNH2 | |
| SCHEMBL18558292 | 0.73 | PTK2 (0.41) | L3MBTL1S1PR3S1PR1S1PR4 | |
| SCHEMBL22538435 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL29872319 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL20447635 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL15486717 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA | |
| SCHEMBL19574036 | 0.73 | ALDH1A1 (0.43) | KDM4EALDH1A1L3MBTL1S1PR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580433-B2 | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-A]pyrazine derivatives as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-28 | — | — | US | disclosed |