Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.31 |
| ▸ | HTR2B | P41595 | 4/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130387 | 0.79 | — | — | |
| SCHEMBL5839553 | 0.76 | ALDH1A1 (0.33) | HTR2CHTR2BSLC6A2HTR2ASLC6A4 | |
| SCHEMBL3464731 | 0.76 | — | — | |
| SCHEMBL5840850 | 0.73 | HTR2C (0.36) | HTR2CHTR2BSLC6A2HTR2ASLC6A4 | |
| SCHEMBL5997071 | 0.72 | NQO2 (0.33) | HTR2B | |
| SCHEMBL3968766 | 0.71 | KDM1A (0.35) | HTR2CHTR2BSLC6A2HTR2ASLC6A4 | |
| SCHEMBL3465174 | 0.70 | — | — | |
| SCHEMBL1768568 | 0.69 | — | — | |
| SCHEMBL1768593 | 0.66 | MAPK1 (0.42) | — | |
| SCHEMBL936930 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10167285-B2 | Small-molecule HSP90 inhibitors | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170342073-A1 | SMALL-MOLECULE HSP90 INHIBITORS | MEMORIAL SLOAN KETTERING CANCER CENTER | 2017-11-30 | — | — | US | disclosed |
| US-9701678-B2 | Small-molecule HSP90 inhibitors | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160333014-A1 | SMALL-MOLECULE HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2016-11-17 | — | — | US | disclosed |
| US-20140227183-A1 | SMALL-MOLECULE HSP90 INHIBITORS | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2014-08-14 | — | — | US | disclosed |
| EP-2725357-A2 | PROBE FOR IFRET AND USAGE OF SAME | Korea Research Institute Of Bioscience And Biotechnology (KR) | 2014-04-30 | — | — | EP | disclosed |
| US-8703942-B2 | Small-molecule Hsp90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-04-22 | — | — | US | disclosed |
| US-20110104054-A1 | Small-Molecule HSP90 Inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-05 | — | — | US | disclosed |
| US-7834181-B2 | Small-molecule Hsp90 inhibitors | SLAON-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-16 | — | — | US | disclosed |
| US-20080253965-A1 | Small-Molecule Hsp90 Inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342073-A1 | SMALL-MOLECULE HSP90 INHIBITORS | HSP90B1, HSP90AB2P, HSP90AB1 | HTR2C 1220/4885HTR2B 923/4885SLC6A2 1370/4885 |
| US-20110104054-A1 | Small-Molecule HSP90 Inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | HTR2C 1861/4885HTR2B 2005/4885SLC6A2 2043/4885 |
| US-20160333014-A1 | SMALL-MOLECULE HSP90 INHIBITORS | HSP90B1, HSP90AB1, HSP90AB2P | HTR2C 2970/4885HTR2B 2812/4885SLC6A2 1994/4885 |
| US-10167285-B2 | Small-molecule HSP90 inhibitors | HSP90B1, HSP90AB2P, HSP90AB1 | HTR2C 1141/4885HTR2B 857/4885SLC6A2 1140/4885 |
| US-20140227183-A1 | SMALL-MOLECULE HSP90 INHIBITORS | HSP90AB2P, HSP90AB1, HSP90B1 | HTR2C 2667/4885HTR2B 2729/4885SLC6A2 2573/4885 |
| US-20080253965-A1 | Small-Molecule Hsp90 Inhibitors | HSP90AB2P, HSP90AB1, HSP90AA1 | HTR2C 2233/4885HTR2B 2543/4885SLC6A2 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.