Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18558516 | 0.96 | HDAC3 (0.39) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18558155 | 0.96 | MAPT (0.41) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18557830 | 0.96 | MAPT (0.41) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18558676 | 0.96 | MAPT (0.40) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18558584 | 0.93 | MAPT (0.44) | ALPLHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18558233 | 0.92 | MAPK1 (0.38) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18558217 | 0.92 | ALPL (0.39) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL19362634 | 0.91 | CA2 (0.39) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL18558161 | 0.91 | ALPL (0.40) | ALPLCA12RPA1HDAC3HDAC4 | |
| SCHEMBL17089807 | 0.91 | HDAC3 (0.36) | ALPLCA12RPA1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932313-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-09-21 | — | — | US | disclosed |
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267643-A1 | PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | ATP5F1A, ATP5F1D, ATP5ME | ALPL 4028/4885CA12 4881/4885RPA1 1520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.