Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 8/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18559525 | 0.88 | MAPK9 (0.42) | MAPK9MAPK10 | |
| SCHEMBL1232424 | 0.86 | MAPK9 (0.59) | MAPK9MAPK10JAK2PRKD3MARK3 | |
| SCHEMBL12901101 | 0.85 | KDM4E (0.43) | MAPK9MAPK10JAK2PRKD3MARK3 | |
| SCHEMBL1232385 | 0.75 | MAPK10 (0.59) | MAPK9MAPK10JAK2MAPK1 | |
| SCHEMBL5212767 | 0.73 | ULK1 (0.47) | JAK2PRKD3MARK3PRKCIPRKCD | |
| SCHEMBL18559417 | 0.72 | MAPK9 (0.49) | MAPK9MAPK10JAK2CYP3A4MAPK1 | |
| SCHEMBL1231947 | 0.72 | KDM4E (0.42) | JAK2PRKD3MARK3PRKCIPRKCD | |
| SCHEMBL5213817 | 0.71 | CDK1 (0.47) | JAK2PRKD3MARK3PRKCIPRKCD | |
| SCHEMBL5216635 | 0.69 | PTK2 (0.45) | JAK2 | |
| SCHEMBL5208214 | 0.69 | PTK2 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580439-B2 | Inhibitors of focal adhesion kinase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-02-28 | — | — | US | disclosed |