Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184989 | 0.91 | BDKRB1 (0.50) | FAAHBDKRB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14856425 | 0.89 | BDKRB1 (0.48) | FAAHBDKRB1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL2805104 | 0.86 | BDKRB1 (0.56) | BDKRB1ALDH1A1LMNACYP3A4CYP2C9 | |
| SCHEMBL202538 | 0.86 | BDKRB1 (0.38) | FAAHBDKRB1ALDH1A1LMNACYP3A4 | |
| SCHEMBL185374 | 0.83 | MEN1 (0.47) | FAAHBDKRB1TRPV1NAMPT | |
| SCHEMBL185958 | 0.83 | BDKRB1 (0.44) | FAAHBDKRB1TRPV1NAMPT | |
| SCHEMBL196872 | 0.82 | BDKRB1 (0.40) | FAAHBDKRB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14857250 | 0.82 | BDKRB1 (0.40) | FAAHBDKRB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL185745 | 0.82 | BDKRB1 (0.43) | FAAHBDKRB1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL185881 | 0.79 | OPRL1 (0.37) | FAAHBDKRB1ALDH1A1LMNATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |