Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 4/20 | 0.40 |
| ▸ | FAAH | O00519 | 6/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805761 | 0.89 | BDKRB1 (0.49) | BDKRB1LRRK2VNN1CTSLCTSB | |
| SCHEMBL14857250 | 0.87 | BDKRB1 (0.40) | BDKRB1FAAHLRRK2TRPV1CTSL | |
| SCHEMBL202538 | 0.83 | BDKRB1 (0.38) | BDKRB1FAAHLRRK2TRPV1VNN1 | |
| SCHEMBL185605 | 0.82 | FAAH (0.46) | BDKRB1FAAHTRPV1CYP3A4CYP2C9 | |
| SCHEMBL184989 | 0.81 | BDKRB1 (0.50) | BDKRB1FAAHTRPV1CYP3A4CYP2C9 | |
| SCHEMBL185311 | 0.80 | BDKRB1 (0.37) | BDKRB1FAAHTRPV1 | |
| SCHEMBL14857225 | 0.79 | BDKRB1 (0.38) | BDKRB1TRPV1NAMPT | |
| SCHEMBL14856784 | 0.78 | FAAH (0.36) | BDKRB1FAAHTRPV1CYP2C9MAPK14 | |
| SCHEMBL186195 | 0.78 | FAAH (0.36) | BDKRB1FAAHTRPV1 | |
| SCHEMBL185655 | 0.78 | BDKRB1 (0.35) | BDKRB1FAAHTRPV1VNN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |