Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.45 |
| ▸ | TUBB | P07437 | 8/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17251712 | 0.82 | PARP1 (0.59) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL17251710 | 0.81 | PDGFRB (0.56) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL17251722 | 0.80 | CDK2 (0.53) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL8818585 | 0.79 | PARP1 (0.62) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL20100921 | 0.75 | BRD4 (0.61) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL17251721 | 0.73 | BRD4 (0.53) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL18562042 | 0.72 | DHODH (0.55) | BRD4PARP1DHODH | |
| SCHEMBL18562043 | 0.72 | PDGFRB (0.49) | BRD4PARP1PDGFRBDHODHAURKA | |
| SCHEMBL18562045 | 0.71 | CDK2 (0.53) | KDR | |
| SCHEMBL18576289 | 0.71 | PDGFRB (0.46) | BRD4PARP1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981915-B2 | Compounds for treatment of cancer | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2018-05-29 | — | — | US | disclosed |
| US-20180118693-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-20170057930-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118693-A1 | COMPOUNDS FOR TREATMENT OF CANCER | TP53, TUBB1, TUBB6 | BRD4 273/4885PARP1 1818/4885TUBB4A 7/4885 |
| US-20170057930-A1 | COMPOUNDS FOR TREATMENT OF CANCER | TP53, TUBB1, TUBB6 | BRD4 273/4885PARP1 1818/4885TUBB4A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.