Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | TEK | Q02763 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17251710 | 0.89 | PDGFRB (0.56) | PDGFRBKDRFLT4FLT3PLK4 | |
| SCHEMBL18562043 | 0.85 | PDGFRB (0.49) | PDGFRBKDRFLT4FLT3PLK4 | |
| SCHEMBL18576291 | 0.84 | CDK2 (0.48) | KDRFLT4FLT3PLK4AURKA | |
| SCHEMBL17251712 | 0.73 | PARP1 (0.59) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL17251722 | 0.72 | CDK2 (0.53) | KDRCDK4CCND1FLT1CCNA2 | |
| SCHEMBL8818585 | 0.71 | PARP1 (0.62) | BRD4PARP1TUBB4ATUBBTUBA3C | |
| SCHEMBL18562035 | 0.71 | BRD4 (0.49) | PDGFRBKDRFLT4FLT3AURKA | |
| SCHEMBL18562042 | 0.69 | DHODH (0.55) | BRD4PARP1AMY1ADHODHPARP2 | |
| SCHEMBL8817550 | 0.68 | PARP1 (0.63) | AURKAPARP1AMY1ADHODHPARP2 | |
| SCHEMBL18562045 | 0.68 | CDK2 (0.53) | KDRCDK4CCND1FLT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170057930-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057930-A1 | COMPOUNDS FOR TREATMENT OF CANCER | TP53, TUBB1, TUBB6 | PDGFRB 3105/4885KDR 3972/4885FLT4 1316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.