Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 1.00 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860157 | 1.00 | HSD11B1 (1.00) | HSD11B1SCD5ROCK2FASN | |
| SCHEMBL1856442 | 1.00 | HSD11B1 (1.00) | HSD11B1SCD5ROCK2FASN | |
| SCHEMBL1860064 | 0.91 | HSD11B1 (0.82) | HSD11B1SCD5ROCK2 | |
| SCHEMBL1860418 | 0.87 | HSD11B1 (0.85) | HSD11B1ROCK2 | |
| SCHEMBL1858468 | 0.86 | HSD11B1 (1.00) | HSD11B1ROCK2 | |
| SCHEMBL3940394 | 0.86 | HSD11B1 (0.82) | HSD11B1ROCK2 | |
| SCHEMBL3929556 | 0.85 | HSD11B1 (0.74) | HSD11B1SCD5ROCK2 | |
| SCHEMBL1856868 | 0.85 | HSD11B1 (0.81) | HSD11B1ROCK2 | |
| SCHEMBL3933608 | 0.84 | HSD11B1 (0.73) | HSD11B1SCD5ROCK2 | |
| SCHEMBL1856402 | 0.83 | HSD11B1 (1.00) | HSD11B1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947834-B2 | Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators | SANOFI-AVENTIS (FR) | 2011-05-24 | — | — | US | disclosed |