Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.81 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860418 | 0.90 | HSD11B1 (0.85) | HSD11B1ROCK2 | |
| SCHEMBL1858468 | 0.89 | HSD11B1 (1.00) | HSD11B1ROCK2 | |
| SCHEMBL3940394 | 0.89 | HSD11B1 (0.82) | HSD11B1ROCK2 | |
| SCHEMBL1856402 | 0.88 | HSD11B1 (1.00) | HSD11B1ROCK2 | |
| SCHEMBL1860266 | 0.87 | HSD11B1 (0.77) | HSD11B1ROCK2 | |
| SCHEMBL1860747 | 0.87 | HSD11B1 (0.75) | HSD11B1ROCK2 | |
| SCHEMBL1862304 | 0.87 | HSD11B1 (0.66) | HSD11B1ROCK2 | |
| SCHEMBL1860793 | 0.86 | HSD11B1 (0.79) | HSD11B1ROCK2 | |
| SCHEMBL1860744 | 0.86 | HSD11B1 (0.79) | HSD11B1ROCK2 | |
| SCHEMBL3932779 | 0.85 | HSD11B1 (0.77) | HSD11B1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947834-B2 | Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators | SANOFI-AVENTIS (FR) | 2011-05-24 | — | — | US | disclosed |
| US-20090176775-A1 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | SANOFI-AVENTIS (FR) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176775-A1 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | HSD11B1, HSD3B1, ADH1C | HSD11B1 1/4885ROCK2 3507/4885GRIN2B 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.