SCHEMBL185645

SCHEMBL185645

CCCC(CC(N)=O)c1ccccc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.40
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
NR3C2 P08235 2/20 0.36
ESR1 P03372 1/20 0.35
CXCR5 P32302 1/20 0.35
ACP3 P15309 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
CTSA P10619 2/20 0.34
POLB P06746 1/20 0.34
CYSLTR2 Q9NS75 1/20 0.34
CYSLTR1 Q9Y271 1/20 0.34
MAPK1 P28482 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11088063 0.88 ALDH1A1 (0.45) ALDH1A1NR3C2ESR1ACP3NPSR1
SCHEMBL185424 0.87 ALDH1A1 (0.42) ALDH1A1NR3C2ESR1ACP3NPSR1
SCHEMBL11287832 0.85 CTSA (0.43) CTSACYSLTR2CYSLTR1
SCHEMBL19612742 0.84 SLC6A2 (0.38) ALDH1A1SLC6A2SLC6A4SLC6A3ESR1
SCHEMBL11278879 0.81 PPARG (0.40) ALDH1A1SLC6A2SLC6A4SLC6A3ESR1
SCHEMBL29048166 0.81 ALDH1A1 (0.45) ALDH1A1NR3C2ESR1ACP3NPSR1
SCHEMBL11366354 0.80 ESR1 (0.46) SLC6A2SLC6A4SLC6A3ESR1ACP3
SCHEMBL15614666 0.78 ALDH1A1 (0.54) ALDH1A1SLC6A3NPSR1LMNAMAPT
SCHEMBL184884 0.78 ALDH1A1 (0.54) ALDH1A1SLC6A3NPSR1LMNAMAPT
SCHEMBL14108456 0.78 ALDH1A1 (0.45) ALDH1A1NR3C2ESR1ACP3NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2401260-A1 DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM Galderma Research & Development (FR) 2012-01-04 EP claimed
WO-2010097465-A1 DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM GALDERMA RESEARCH & DEVELOPMENT (FR) 2010-09-02 WO claimed
EP-2401260-A1 DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM Galderma Research & Development (FR) 2012-01-04 EP disclosed
WO-2010097465-A1 DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM GALDERMA RESEARCH & DEVELOPMENT (FR) 2010-09-02 WO disclosed