Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856848 | 1.00 | HSD11B1 (0.71) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| SCHEMBL1854997 | 0.94 | HSD11B1 (0.79) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| Hydrochloric Acid SCHEMBL1857334 | 0.93 | HSD11B1 (0.78) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| SCHEMBL3932825 | 0.86 | HSD11B1 (0.66) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| SCHEMBL1857858 | 0.86 | HSD11B1 (0.66) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| SCHEMBL1860172 | 0.84 | HSD11B1 (0.62) | HSD11B1SMN1; SMN2SMOPOLBTSHR | |
| SCHEMBL5421718 | 0.84 | HSD11B1 (0.78) | HSD11B1SMN1; SMN2SMOPOLBNOTUM | |
| SCHEMBL1860343 | 0.83 | HSD11B1 (0.68) | HSD11B1SMN1; SMN2SMOPOLBNOTUM | |
| SCHEMBL1856555 | 0.83 | HSD11B1 (0.67) | HSD11B1SMN1; SMN2SMOPOLBHSD17B10 | |
| SCHEMBL4171896 | 0.83 | HSD11B1 (1.00) | HSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947834-B2 | Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators | SANOFI-AVENTIS (FR) | 2011-05-24 | — | — | US | disclosed |