Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.31 |
| ▸ | FAAH | O00519 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14857218 | 0.92 | MAPK7 (0.32) | FGFR4P2RX7OPRL1TRPV1FAAH | |
| SCHEMBL2806537 | 0.90 | P2RX7 (0.34) | CCNCCDK8P2RX7JAK1JAK3 | |
| SCHEMBL14856567 | 0.89 | OPRL1 (0.35) | CCNCCDK8OPRL1TRPV1FAAH | |
| SCHEMBL14856773 | 0.87 | CNR2 (0.34) | CCNCCDK8P2RX7TRPV1FAAH | |
| SCHEMBL14856726 | 0.86 | FAAH (0.35) | FGFR4CCNCCDK8JAK1JAK3 | |
| SCHEMBL2807071 | 0.85 | BDKRB1 (0.35) | P2RX7OPRL1PTGES | |
| SCHEMBL185684 | 0.85 | BDKRB1 (0.35) | P2RX7OPRL1PTGES | |
| Hydrochloric Acid SCHEMBL185917 | 0.85 | FAAH (0.32) | OPRL1TRPV1FAAH | |
| SCHEMBL2810139 | 0.84 | BDKRB1 (0.36) | P2RX7OPRL1EGFRPTGES | |
| SCHEMBL186187 | 0.84 | TRPV1 (0.36) | P2RX7TRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |