Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 13/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 12/20 | 1.00 |
| ▸ | MRGPRX2 | Q96LB1 | 3/20 | 0.70 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876355 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| SCHEMBL22838355 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| SCHEMBL8383142 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| SCHEMBL14089349 | 0.88 | OPRD1 (0.78) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| SCHEMBL30199760 | 0.85 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL21008992 | 0.85 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL18569385 | 0.85 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2 | |
| SCHEMBL19235930 | 0.84 | OPRM1 (0.73) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL24599520 | 0.83 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL13154676 | 0.83 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342427-A1 | PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE | Nektar Therapeutics (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-2628489-B1 | PEG oligomer-fentanyl conjugates | NEKTAR THERAPEUTICS (US) | 2017-03-01 | — | — | EP | disclosed |