Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.61 |
| ▸ | FDPS | P14324 | 3/20 | 0.58 |
| ▸ | PTGES | O14684 | 5/20 | 0.57 |
| ▸ | TOP2A | P11388 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30884508 | 1.00 | NFE2L2 (0.61) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18544331 | 0.99 | NFE2L2 (0.63) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18544330 | 0.99 | NFE2L2 (0.63) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18570056 | 0.99 | NFE2L2 (0.60) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18544315 | 0.96 | NFE2L2 (0.56) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18544316 | 0.96 | NFE2L2 (0.56) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18570023 | 0.96 | NFE2L2 (0.56) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL18544371 | 0.95 | NFE2L2 (0.55) | NFE2L2FDPSPTGESTOP2AAPP | |
| SCHEMBL20506836 | 0.95 | APP (0.62) | NFE2L2PTGESTOP2AAPPKDM4E | |
| SCHEMBL18569796 | 0.95 | APP (0.62) | NFE2L2PTGESTOP2AAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220054671-A1 | 1,7-DIARYL-1,6-HEPTADIENE-3,5-DIONE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2022-02-24 | — | — | US | disclosed |
| US-11191855-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2021-12-07 | — | — | US | disclosed |
| WO-2017032892-A1 | 1,7-DIARYL-1,6-HEPTADIENE-3,5-DIONE DERIVATIVES, METHODS FOR THE PRODCUTION AND USE THEREOF | UNIVERSITÄTSKLINIKUM REGENSBURG (DE) | 2017-03-02 | — | — | WO | disclosed |
| EP-3135110-A1 | 1,7-DIARYL-1,6-HEPTADIEN-3,5-DION DERIVATIVES, METHODS OF MAKING AND USING THE SAME | Universitätsklinikum Regensburg (DE) | 2017-03-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220054671-A1 | 1,7-DIARYL-1,6-HEPTADIENE-3,5-DIONE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF | DHPS, SQLE, CYP51A1 | NFE2L2 1038/4885FDPS 28/4885PTGES 97/4885 |
| US-11191855-B2 | 1,7-diaryl-1,6-heptadiene-3,5-dione derivatives, methods for the production and use thereof | DHPS, SQLE, CYP51A1 | NFE2L2 1038/4885FDPS 28/4885PTGES 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.