Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 5/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.55 |
| ▸ | PTGES | O14684 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | TOP2A | P11388 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30884508 | 0.95 | NFE2L2 (0.61) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18569800 | 0.95 | NFE2L2 (0.61) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18569780 | 0.94 | APP (0.53) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL20506836 | 0.94 | APP (0.62) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18569796 | 0.94 | APP (0.62) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18544331 | 0.94 | NFE2L2 (0.63) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18544330 | 0.94 | NFE2L2 (0.63) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18570056 | 0.94 | NFE2L2 (0.60) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL18570051 | 0.94 | APP (0.52) | APPMAPTBACE1NFE2L2PTGES | |
| SCHEMBL30884499 | 0.94 | APP (0.52) | APPMAPTBACE1NFE2L2PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3135110-A1 | 1,7-DIARYL-1,6-HEPTADIEN-3,5-DION DERIVATIVES, METHODS OF MAKING AND USING THE SAME | Universitätsklinikum Regensburg (DE) | 2017-03-01 | — | — | EP | disclosed |