Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7927301 | 0.84 | ALDH1A1 (0.57) | TDP1ALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL28657572 | 0.84 | APP (0.50) | APPSCN8ASCN10AALDH1A1HTT | |
| SCHEMBL20182409 | 0.78 | MAPT (0.45) | TDP1ALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL30933896 | 0.77 | ALDH1A1 (0.49) | TDP1ALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL28916081 | 0.77 | SMN1; SMN2 (0.44) | TDP1ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL18725098 | 0.77 | MAOB (0.51) | APPTDP1HPGDKCNH2MAOB | |
| SCHEMBL20182410 | 0.75 | MAPT (0.48) | TDP1ALDH1A1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL18570626 | 0.75 | SCN8A (0.46) | APPSCN8ASCN10AALDH1A1HTT | |
| SCHEMBL7088703 | 0.74 | TDP1 (0.50) | TDP1ALDH1A1HPGDMAOBERN1 | |
| SCHEMBL3329518 | 0.74 | HPGD (0.51) | TDP1ALDH1A1HPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |