Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 4/20 | 0.37 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18022791 | 0.77 | POLB (0.50) | NNMTPDE10ACYP1A2KMT2APOLB | |
| SCHEMBL172558 | 0.76 | NNMT (0.52) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL4977234 | 0.74 | KDM4E (0.52) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL26137908 | 0.74 | KMT2A (0.44) | CYP1A2KMT2ATDP1 | |
| SCHEMBL18774086 | 0.73 | NNMT (0.48) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL357334 | 0.73 | NNMT (0.53) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL12093130 | 0.73 | NNMT (0.48) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL13865700 | 0.73 | NNMT (0.48) | NNMTPDE10ACYP1A2KMT2APDE2A | |
| SCHEMBL586103 | 0.73 | NNMT (0.53) | NNMTPDE10ACYP1A2KMT2APOLB | |
| SCHEMBL1461146 | 0.73 | NNMT (0.48) | NNMTPDE10ACYP1A2KMT2APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964627-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |