Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.54 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570708 | 0.86 | SCN8A (0.49) | ARSCN8ASCN10ASLC6A4ESRRA | |
| SCHEMBL19563734 | 0.83 | AR (0.49) | ARSCN8ASCN10ASLC6A4ESRRA | |
| SCHEMBL1398327 | 0.82 | ALDH1A1 (0.58) | ARERN1ALDH1A1 | |
| SCHEMBL29955071 | 0.82 | ALDH1A1 (0.58) | ARERN1ALDH1A1 | |
| SCHEMBL18570618 | 0.80 | SCN8A (0.47) | SCN8ASCN10ASLC6A4ERN1ALDH1A1 | |
| SCHEMBL19524117 | 0.80 | ERN1 (0.50) | ERN1ALDH1A1 | |
| SCHEMBL18570705 | 0.80 | SCN8A (0.46) | ARSCN8ASCN10ASLC6A4ALDH1A1 | |
| SCHEMBL4175734 | 0.79 | AR (0.59) | ARSCN8ASCN10ASLC6A4ESRRA | |
| SCHEMBL18570740 | 0.78 | SCN8A (0.49) | SCN8ASCN10AERN1ESRRAALDH1A1 | |
| SCHEMBL23246582 | 0.78 | AR (0.49) | ARSLC6A4ESRRAALDH1A1ESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-3022175-B1 | SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3239134-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |