Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809753 | 0.83 | SCN8A (0.47) | SCN8ASCN10AEPAS1L3MBTL1MRGPRX4 | |
| SCHEMBL19563735 | 0.82 | SCN8A (0.46) | SCN8ASCN10AEPAS1ALDH1A1 | |
| SCHEMBL22809756 | 0.79 | SCN8A (0.46) | SCN8ASCN10AEPAS1ALOX5APFEN1 | |
| SCHEMBL18570715 | 0.78 | SCN8A (0.49) | SCN8ASCN10ACYP2C9L3MBTL1ALDH1A1 | |
| SCHEMBL18570579 | 0.78 | L3MBTL1 (0.46) | SCN8ASCN10AEPAS1CYP2C9L3MBTL1 | |
| SCHEMBL19563643 | 0.77 | SCN8A (0.47) | SCN8ASCN10AEPAS1MRGPRX4MEN1 | |
| SCHEMBL19563616 | 0.77 | SCN10A (0.47) | SCN8ASCN10A | |
| SCHEMBL269221 | 0.77 | BACE1 (0.47) | ALOX5APFEN1BACE1IDO1CYP2C9 | |
| SCHEMBL19563652 | 0.77 | HTR2A (0.51) | SCN8ASCN10AEPAS1CYP2C9CYP2D6 | |
| SCHEMBL19524181 | 0.77 | SCN10A (0.46) | SCN8ASCN10AL3MBTL1MRGPRX4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |