Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988752 | 0.90 | SCN8A (0.47) | SCN8ASCN10ABRD4EPAS1CYP1A1 | |
| SCHEMBL275968 | 0.86 | HSPB1 (0.46) | EPAS1HSPB1ALDH1A1HTTTRPA1 | |
| SCHEMBL19563643 | 0.86 | SCN8A (0.47) | SCN8ASCN10AEPAS1 | |
| SCHEMBL22809753 | 0.86 | SCN8A (0.47) | SCN8ASCN10AEPAS1 | |
| SCHEMBL19563616 | 0.86 | SCN10A (0.47) | SCN8ASCN10A | |
| SCHEMBL18570369 | 0.85 | SCN8A (0.48) | SCN8ASCN10AEPAS1ALDH1A1 | |
| SCHEMBL18570597 | 0.85 | SCN8A (0.48) | SCN8ASCN10AALDH1A1 | |
| SCHEMBL18570724 | 0.85 | SCN8A (0.48) | SCN8ASCN10AALDH1A1 | |
| SCHEMBL18570579 | 0.84 | L3MBTL1 (0.46) | SCN8ASCN10AEPAS1ALDH1A1 | |
| SCHEMBL18570715 | 0.83 | SCN8A (0.49) | SCN8ASCN10ACYP1A1CYP1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022175-B1 | SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-11-08 | — | — | EP | disclosed |