Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5991545 | 0.81 | SCN8A (0.47) | SCN8ASCN10APOLBMAPTNPSR1 | |
| SCHEMBL4661838 | 0.79 | SCN8A (0.62) | SCN8ASCN10AHTR2AHTR2CHTR2B | |
| SCHEMBL4661893 | 0.77 | SCN8A (0.48) | SCN8ASCN10AHTR2AHTR2CHTR2B | |
| SCHEMBL18570359 | 0.77 | SCN8A (0.51) | SCN8ASCN10AHTR2AMAP4K4POLB | |
| SCHEMBL18570602 | 0.76 | SCN10A (0.48) | SCN8ASCN10A | |
| SCHEMBL18570945 | 0.76 | SCN8A (0.47) | SCN8ASCN10APDE10APDE2APOLB | |
| SCHEMBL18570545 | 0.75 | SCN8A (0.52) | SCN8ASCN10APDE10AHTR2AHTR2C | |
| SCHEMBL18570362 | 0.74 | HTR2A (0.52) | SCN8ASCN10AHTR2APOLBMAPT | |
| SCHEMBL22809693 | 0.74 | SCN8A (0.48) | SCN8ASCN10APOLBMAPTNPSR1 | |
| SCHEMBL2657080 | 0.74 | CYP1A2 (0.46) | SCN8ASCN10AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |