Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.52 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.52 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 2/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CCR9 | P51686 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570617 | 0.79 | SCN8A (0.49) | SCN8ASCN10ANPSR1ALDH1A1LMNA | |
| SCHEMBL18570710 | 0.76 | SCN8A (0.45) | SCN8ASCN10ANPSR1ALDH1A1LMNA | |
| SCHEMBL18570698 | 0.76 | SCN8A (0.47) | SCN8ASCN10AALDH1A1 | |
| SCHEMBL6500895 | 0.75 | GPR3 (0.42) | ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL18570624 | 0.75 | SCN8A (0.50) | SCN8ASCN10ANPSR1PDE10AALDH1A1 | |
| SCHEMBL18570714 | 0.75 | SCN10A (0.50) | SCN8ASCN10AALDH1A1LMNACYP1A2 | |
| SCHEMBL1985337 | 0.74 | TUBB1 (0.51) | RUNX1ALPLALDH1A1CYP1A2 | |
| SCHEMBL19524141 | 0.74 | SCN8A (0.51) | SCN8ASCN10ANPSR1ALDH1A1LMNA | |
| SCHEMBL3897242 | 0.74 | PDGFRA (0.56) | — | |
| SCHEMBL18570685 | 0.73 | SCN8A (0.49) | SCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |