Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809605 | 0.89 | SCN8A (0.47) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL22809693 | 0.83 | SCN8A (0.48) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL5991545 | 0.83 | SCN8A (0.47) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL18570392 | 0.81 | SCN8A (0.46) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL4613870 | 0.81 | LMNA (0.57) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL20638988 | 0.79 | ALDH1A1 (0.48) | SCN8ASCN10AMAPTKDM4EL3MBTL1 | |
| SCHEMBL5988752 | 0.77 | SCN8A (0.47) | SCN8ASCN10AALDH1A1HTT | |
| SCHEMBL18570740 | 0.77 | SCN8A (0.49) | SCN8ASCN10AALDH1A1 | |
| SCHEMBL5988928 | 0.77 | SCN8A (0.45) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL96815 | 0.76 | ALDH1A1 (0.55) | LMNAGAAKMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |