Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857067 | 1.00 | AKR1C3 (0.46) | AKR1C3AKR1C1GPR183HDAC1HDAC6 | |
| SCHEMBL1868213 | 0.88 | HDAC1 (0.61) | GPR183HDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL1868212 | 0.88 | HDAC1 (0.61) | GPR183HDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL8993536 | 0.85 | PKM (0.54) | GPR183HDAC1HDAC6HDAC3HDAC8 | |
| SCHEMBL295731 | 0.83 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC8PKM | |
| SCHEMBL295732 | 0.83 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC8PKM | |
| SCHEMBL1864225 | 0.83 | HDAC1 (0.42) | AKR1C3AKR1C1GPR183HDAC1HDAC6 | |
| SCHEMBL1864228 | 0.83 | HDAC1 (0.42) | AKR1C3AKR1C1GPR183HDAC1HDAC6 | |
| SCHEMBL295857 | 0.82 | HDAC1 (0.43) | HDAC1HDAC6HDAC3HDAC8PKM | |
| SCHEMBL295856 | 0.82 | HDAC1 (0.43) | HDAC1HDAC6HDAC3HDAC8PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868994-B1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2011-05-25 | — | — | EP | disclosed |
| US-20090117074-A1 | Sulfonylpyrroles as Histone Deacetylase Inhibitors | NYCOMED GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| EP-1868994-A1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | Nycomed GmbH (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105979-A1 | SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS | NYCOMED GMBH (DE) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090117074-A1 | Sulfonylpyrroles as Histone Deacetylase Inhibitors | HDAC1, HDAC3, HDAC2 | AKR1C3 3261/4885AKR1C1 1834/4885GPR183 3563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.