Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 11/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570394 | 0.91 | SCN10A (0.52) | SCN10ASCN8ASCN9A | |
| SCHEMBL22809751 | 0.86 | SCN10A (0.51) | SCN10ASCN8ASCN9A | |
| SCHEMBL18570359 | 0.86 | SCN8A (0.51) | SCN10ASCN8APOLBMAPTALDH1A1 | |
| SCHEMBL14147855 | 0.80 | SCN8A (0.50) | SCN10ASCN8AMAPTL3MBTL1 | |
| SCHEMBL5988928 | 0.79 | SCN8A (0.45) | SCN10ASCN8APOLBMAPTALDH1A1 | |
| SCHEMBL14661987 | 0.78 | SCN9A (0.47) | SCN10ASCN9A | |
| SCHEMBL3656855 | 0.78 | SCN8A (0.62) | SCN10ASCN8ASCN9AALDH1A1 | |
| SCHEMBL18570392 | 0.78 | SCN8A (0.46) | SCN10ASCN8APOLBMAPTALDH1A1 | |
| SCHEMBL18570362 | 0.78 | HTR2A (0.52) | SCN10ASCN8APOLBMAPTALDH1A1 | |
| SCHEMBL4613870 | 0.77 | LMNA (0.57) | SCN10ASCN8APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |