Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.53 |
| ▸ | TK1 | P04183 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820020 | 0.86 | TYMS (0.51) | TYMSTK1POLB | |
| SCHEMBL6386144 | 0.85 | TK1 (0.48) | TYMSTK1POLB | |
| SCHEMBL7038113 | 0.80 | TK1 (0.49) | TYMSTK1 | |
| SCHEMBL25752637 | 0.79 | TK1 (0.60) | TYMSTK1POLB | |
| SCHEMBL25756099 | 0.79 | TK1 (0.60) | TYMSTK1POLB | |
| SCHEMBL7201324 | 0.79 | TK1 (0.60) | TYMSTK1POLB | |
| SCHEMBL25700727 | 0.79 | TK1 (0.60) | TYMSTK1POLB | |
| SCHEMBL6661323 | 0.79 | TK1 (0.51) | TK1POLB | |
| Doxribtimine SCHEMBL20797965 | 0.77 | TYMS (0.63) | TYMSTK1POLB | |
| Thymidine Monophosphate SCHEMBL20797966 | 0.77 | TYMS (0.75) | TYMSTK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242631-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | LEGOCHEM BIOSCIENCES, INC. (KR) | 2023-12-21 | — | — | WO | disclosed |
| US-20210401950-A1 | COMPOSITIONS FOR TREATING PATHOLOGICAL CALCIFICATION CONDITIONS, AND METHODS USING SAME | UNIV YALE (US) | 2021-12-30 | — | — | US | disclosed |
| US-11123408-B2 | Compositions and methods for treating nonsteroidal anti-inflammatory drug (NSAID) associated coagulopathy, thrombocytopenia, glanzmann's thrombasthenia, and/or thrombosis | YALE UNIVERSITY (US) | 2021-09-21 | — | — | US | disclosed |
| US-20190167768-A1 | COMPOSITIONS AND METHODS FOR TREATING NONSTEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) ASSOCIATED COAGULOPATHY, THROMBOCYTOPENIA, GLANZMANN'S THROMBASTHENIA, AND/OR THROMBOSIS | UNIV YALE (US) | 2019-06-06 | — | — | US | disclosed |
| US-10258671-B2 | Compositions and methods for treating platelet storage pool deficiency, gray platelet syndrome and quebec platelet disorder | YALE UNIVERSITY (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180169192-A1 | Compositions and Methods for Modulating Coagulation | UNIV YALE (US) | 2018-06-21 | — | — | US | disclosed |
| US-9867870-B2 | Compositions and methods for treating hemophilia | YALE UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170274054-A1 | Compositions and Methods for Modulating Coagulation | UNIV YALE (US) | 2017-09-28 | — | — | US | disclosed |
| US-9642896-B1 | Compositions and methods for modulating coagulation | YALE UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20110110886-A1 | SMALL MOLECULE INHIBITORS OF AUTOTAXIN AND METHODS OF USE | YALE UNIVERSITY | 2011-05-12 | — | — | US | disclosed |
| EP-1664081-A2 | NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME | Curagen Corporation (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1448991-A2 | ACTIVATED ENZYME-LINKED DETECTION SYSTEMS FOR DETECTING AND QUANTIFYING NUCLEID ACIDS, ANTIGENS, ANTIBODIES AND OTHER ANALYTES | FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2004-08-25 | — | — | EP | disclosed |
| WO-2004048512-A2 | NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME | CURAGEN CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20030153730-A1 | Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy | STRACKE MARY (US) | 2003-08-14 | — | — | US | disclosed |
| WO-2002082078-A2 | ACTIVATED ENZYME-LINKED DETECTION SYSTEMS FOR DETECTING AND QUANTIFYING NUCLEID ACIDS, ANTIGENS ANTIBODIES AND OTHER ANALYTES | FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2002-10-17 | — | — | WO | disclosed |
| US-6417338-B1 | ACCUMULATION, CONCENTRATION OF POLYPEPTIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2002-07-09 | — | — | US | disclosed |
| US-6084069-A | AMINO ACID SEQUENCES; FOR ANTITUMOR/ANTICARCINOGENIC AGENTS; ANTIMETASTASIS/ANTIINFLAMMATORY/ANTIFIBROTIC AGENTS; TREATMENT OF INFECTIONS AND HEALING DISORDERS; DIAGNOSIS OF RELATED DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-07-04 | — | — | US | disclosed |
| US-5731167-A | DNA SEGMENT CODING FOR A POLYPEPTIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-03-24 | — | — | US | disclosed |
| WO-1995032221-A9 | AUTOTAXIN: MOTILITY STIMULATING PROTEIN USEFUL IN CANCER DIAGNOSIS AND THERAPY | — | 1996-01-04 | — | — | WO | disclosed |
| WO-1995032221-A2 | AUTOTAXIN: MOTILITY STIMULATING PROTEIN USEFUL IN CANCER DIAGNOSIS AND THERAPY | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110110886-A1 | SMALL MOLECULE INHIBITORS OF AUTOTAXIN AND METHODS OF USE | ENPP2, LPCAT3, LPAR1 | TYMS 2916/4885TK1 688/4885POLB 1543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.