Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | NNMT | P40261 | 14/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109736 | 1.00 | AHCY (0.52) | AHCYADORA2BNNMTPRMT5WDR77 | |
| SCHEMBL18572585 | 1.00 | AHCY (0.52) | AHCYADORA2BNNMTPRMT5WDR77 | |
| SCHEMBL29540101 | 0.89 | NNMT (0.43) | AHCYADORA2BNNMTPRMT5WDR77 | |
| SCHEMBL22509889 | 0.89 | NNMT (0.43) | AHCYADORA2BNNMTPRMT5WDR77 | |
| SCHEMBL9469927 | 0.86 | NNMT (0.42) | NNMTPRMT5WDR77 | |
| SCHEMBL24465141 | 0.85 | PRMT5 (0.67) | AHCYADORA2BPRMT5WDR77 | |
| SCHEMBL18571689 | 0.85 | PRMT5 (0.67) | AHCYADORA2BPRMT5WDR77 | |
| SCHEMBL29325375 | 0.85 | PRMT5 (0.67) | AHCYADORA2BPRMT5WDR77 | |
| SCHEMBL10186262 | 0.85 | AHCY (0.52) | AHCYADORA2BPRMT5WDR77 | |
| SCHEMBL29323387 | 0.85 | PRMT5 (0.67) | AHCYADORA2BPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220205026-A1 | Use of Biomarkers in Identifying Cancer Patients That Will Be Responsive to Treatment With a PRMT5 Inhibitor | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-30 | — | — | US | disclosed |
| US-11318157-B2 | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-03 | — | — | US | disclosed |
| US-20200360416-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-11-19 | — | — | US | disclosed |
| US-10653711-B2 | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11318157-B2 | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors | PRMT5, PRMT6, PRMT1 | AHCY 333/4885ADORA2B 2067/4885NNMT 18/4885 |
| US-20200360416-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | PRMT5, PRMT6, PRMT1 | AHCY 290/4885ADORA2B 2411/4885NNMT 20/4885 |
| US-10653711-B2 | 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors | PRMT5, PRMT6, PRMT1 | AHCY 333/4885ADORA2B 2067/4885NNMT 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.