Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 12/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24067750 | 0.84 | ALDH1A1 (0.33) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL25951483 | 0.80 | KMT2A (0.38) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL18572275 | 0.80 | KMT2A (0.38) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL22002062 | 0.79 | ALDH1A1 (0.34) | ALDH1A1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL25951474 | 0.75 | KMT2A (0.37) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL23892464 | 0.72 | KMT2A (0.38) | ALDH1A1KMT2AMEN1MAPTNPC1 | |
| SCHEMBL18571963 | 0.70 | RXFP1 (0.37) | PRMT5WDR77KMT2AMEN1MAPT | |
| SCHEMBL18571954 | 0.70 | KMT2A (0.36) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL22002061 | 0.70 | KMT2A (0.36) | ALDH1A1PRMT5WDR77KMT2AMEN1 | |
| SCHEMBL22684499 | 0.68 | PRMT5 (0.44) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |