Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572275 | 1.00 | KMT2A (0.38) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL18571963 | 0.87 | RXFP1 (0.37) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL22002061 | 0.83 | KMT2A (0.36) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL18571954 | 0.83 | KMT2A (0.36) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL18572278 | 0.80 | ALDH1A1 (0.33) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL18571918 | 0.79 | PRMT5 (0.42) | PRMT5WDR77RAPGEF3 | |
| SCHEMBL25951474 | 0.77 | KMT2A (0.37) | KMT2ATDP1MEN1MAPTNPC1 | |
| SCHEMBL21089769 | 0.77 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL22683096 | 0.76 | RXFP1 (0.49) | PRMT5WDR77RXFP1RAPGEF3 | |
| SCHEMBL18572012 | 0.76 | RXFP1 (0.49) | PRMT5WDR77RXFP1RAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |