Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856590 | 0.94 | FAAH (0.35) | FAAHTRPV1NTRK1P2RX7BDKRB1 | |
| SCHEMBL185388 | 0.93 | OPRL1 (0.36) | FAAHTRPV1NTRK1P2RX7CNR2 | |
| SCHEMBL14856503 | 0.90 | FAAH (0.39) | FAAHTRPV1NTRK1P2RX7BDKRB1 | |
| SCHEMBL2805917 | 0.88 | HDAC3 (0.38) | NTRK1P2RX7BDKRB1CNR2AURKA | |
| SCHEMBL14856439 | 0.87 | FAAH (0.33) | FAAHTRPV1NTRK1P2RX7BDKRB1 | |
| SCHEMBL185944 | 0.87 | FAAH (0.36) | FAAHTRPV1NTRK1BDKRB1CNR2 | |
| SCHEMBL185516 | 0.87 | OPRL1 (0.36) | FAAHTRPV1NTRK1P2RX7CNR2 | |
| SCHEMBL185729 | 0.86 | CNR2 (0.35) | FAAHTRPV1P2RX7CNR2OPRL1 | |
| SCHEMBL14856684 | 0.86 | CNR2 (0.37) | FAAHTRPV1P2RX7CNR2DHODH | |
| SCHEMBL14856809 | 0.85 | OPRL1 (0.35) | FAAHTRPV1BDKRB1CNR2OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |