Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 4/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856590 | 0.93 | FAAH (0.35) | FAAHTRPV1BDKRB1DHODHNTRK1 | |
| SCHEMBL186281 | 0.93 | OPRL1 (0.36) | FAAHTRPV1DHODHNTRK1P2RX7 | |
| SCHEMBL2807780 | 0.90 | BDKRB1 (0.41) | BDKRB1DHODHNTRK1P2RX7CNR2 | |
| SCHEMBL185740 | 0.87 | FAAH (0.35) | FAAHTRPV1BDKRB1DHODHNTRK1 | |
| SCHEMBL185516 | 0.86 | OPRL1 (0.36) | FAAHTRPV1DHODHNTRK1P2RX7 | |
| SCHEMBL14856684 | 0.85 | CNR2 (0.37) | FAAHTRPV1DHODHP2RX7CNR2 | |
| SCHEMBL14856700 | 0.84 | FAAH (0.38) | FAAHTRPV1BDKRB1DHODHNTRK1 | |
| SCHEMBL186543 | 0.84 | OPRL1 (0.34) | FAAHTRPV1BDKRB1P2RX7CNR2 | |
| SCHEMBL2805695 | 0.83 | OPRL1 (0.37) | BDKRB1DHODHCNR2OPRL1 | |
| SCHEMBL2805193 | 0.83 | HDAC3 (0.38) | BDKRB1DHODHNTRK1P2RX7CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |